Table 2.2.3, Tolerance Summary for Trinexapac-ethyl summarizes these differences on page 8 of the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed which is located in docket ID number EPA-HQ-OPP-2010-0524. Similarly, EPA does not believe that the non-dietary residential exposures are underestimated because they are based on the conservative assumptions of EPA's Draft Standard Operating Procedures (SOPs) for Residential Exposure Assessments (December 1997), and updates contained in the Science Advisory Council Policy 12 (February 2001) as well as the uses specified in the proposed labels. EPA's aggregate exposure assessment incorporated this additional dietary exposure, as well as exposure in drinking water and from residential sources, although those latter exposures are not impacted by the modified use on sugarcane and thus have not changed since the last assessment. documents in the last year, 1479 All objections and requests for a hearing must be in writing, and must be received by the Hearing Clerk on or before January 4, 2021. The mutagenicity database is also complete, with no evidence of mutagenicity. Specific information on the studies received and the nature of the adverse effects caused by trinexapac-ethyl as well as the no-observed-adverse-effect-level and the lowest-observed-adverse-effect-level from the toxicity studies can be found at http://www.regulations.gov in the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed p. 48 in docket ID number EPA-HQ-OPP-2010-0524. tradeKorea is a online B2B trade website offers you matching services to connect buyers and suppliers. The President of the United States manages the operations of the Executive branch of Government through Executive orders. Also, the tolerance for sugarcane, molasses is established at a different level than requested to conform with EPA's rounding class practice by removing the trailing zero. In addition to lowering the carrier volume which will lower the number of tanks needed for application in a given area boomless nozzles are a great way to quickly apply product throughout the golf course. The Public Inspection page may also Although there is evidence of susceptibility in the rat and rabbit developmental studies and in the rat reproduction study, EPA's concern for these effects is low, and there are no residual uncertainties since the effects only occurred at the highest doses tested (360-1,200 mg/kg/day), for each study, and there were clearly identified NOAELs (60-593 mg/kg/day) for each fetal/offspring effect. Discharge into the environment must be avoided. Chemical Review Manager: Kelly Ballard (ballard.kelly@epa.gov), 703-305-8126. Schedule for Beginning Reviews. better and aid in comparing the online edition to the print edition. Due to the low acute toxicity of trinexapac-ethyl the allocation of an ARfD, and hence an acute consumer risk assessment was not considered necessary. Use this link for bookmarking this species for future reference. Section 408(b)(2)(C) of FFDCA requires EPA to give special consideration to exposure of infants and children to the pesticide chemical residue in establishing a tolerance and to ensure that there is a reasonable certainty that no harm will result to infants and children from aggregate exposure to the pesticide chemical residue. The product may cause mild eye irritation. The Codex Alimentarius is a joint U.N. Food and Agriculture Organization/World Health Organization food standards program, and it is recognized as an international food safety standards-setting organization in trade agreements to which the United States is a party. Lodging occurs due to a variety of factors, and as shown in the figure below, the timing of lodging will determine the final impact on grain yield. 101 Madison Avenue publication in the future. In the mouse, there was no evidence of carcinogenicity. This action does not contain any information collections subject to OMB approval under the Paperwork Reduction Act (PRA) (44 U.S.C. documents in the last year, 983 3. Based upon review of the data supporting the petition, EPA is modifying the tolerance expression and the tolerance for sugarcane, molasses at a different level than petitioned-for. About the Federal Register There were no differences in grain yield at Stillwater or Chickasha in 2014. Further information about EPA's risk assessment and determination of safety can be found at http://www.regulations.gov in the document titled Trinexapac-ethyl. regulatory information on FederalRegister.gov with the objective of Evidence of increased susceptibility to offspring exists at or above the limit dose of the developmental and reproduction studies. In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). As those sections continue to reflect the Agency's current position on those topics, those sections are incorporated here by reference. iii. . New Documents Buy high purity Trinexapac-ethyl analytical standards from Chem Service Inc. Shop N-13706-250MG today for special offers and discounted shipping. provide legal notice to the public or judicial notice to the courts. These 180-degree nozzles can be used without the need to raise and lower booms, which makes applications easier where maneuverability is limited. 5. documents in the last year, 522 This document has been published in the Federal Register. In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). Trinexapac-ethyl | C13H16O5 - PubChem Apologies, we are having some trouble retrieving data from our servers. Based on the lack of evidence of carcinogenicity in two adequate rodent carcinogenicity studies, trinexapac-ethyl is not expected to pose a cancer risk to humans. on This citizen's comment appears to be directed at the underlying statute and not EPA's implementation of it; the citizen has made no contention that EPA has acted in violation of the statutory framework. Similar lesions were not observed in the rat or mouse following acute, subchronic or chronic dietary exposure, and there was no other evidence in any other species tested to indicate a neurotoxicity potential. Establish reliable relationship between buyers and suppliers through our matching services and find new business opportunities through various online exhibitions. As a result, individuals can be exposed by entering these areas if they have been previously treated. Golf faces challenges and opportunities that are vital to its long-term health. Liquid formulations containing organic solvents may be flammable. To access the OCSPP test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select Test Methods and Guidelines.. In the mouse, there was no evidence of carcinogenicity. Research has shown that increasing the soil water content from 17 to 26% reduced the force required for anchorage failure by 33%, and as little as 0.25 inches of water plus 11 mph winds were enough to cause lodging. The analysis and recommendations made in this blog post are based on research findings from 2013 and 2014 production years. documents in the last year, 87 Trinexapac-ethyl. This regulation establishes tolerances for residues of trinexapac-ethyl in or on multiple commodities which are identified and discussed later in this document. Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. that agencies use to create their documents. Upon review of the available information, EPA concludes that these tolerances would be safe. offers a preview of documents scheduled to appear in the next day's Counts are subject to sampling, reprocessing and revision (up or down) throughout the day. Other types of entities not listed in this unit could also be affected. EPA's assessment of exposures and risks associated with trinexapac-ethyl follows. If you are worried about bronzing, tank mix a product that contains manganese rather than iron. Trinexapac-ethyl; tolerances for residues. documents in the last year, 983 Submit the non-CBI copy of your objection or hearing request, identified by docket ID number EPA-HQ-OPP-2020-0046, by one of the following methods: Additional instructions on commenting or visiting the docket, along with more information about dockets generally, is available at http://www.epa.gov/dockets. If these high yield potential acres are being sprayed with a growth regulator at GS 7, the addition of a foliar fungicide might be prudent if it can be included at a relatively low cost. Furthermore, the brain lesions observed in the chronic dog study were not observed in the sub-chronic dog study up to 890 mg/kg/day and are thus not likely to develop from a short-term exposure. Common Name Trade Name(s) Amicarbazone -Xonerate 70WDG Aminoclopyrachlor -Imprelis 80DF, 2SL Aminoclopyrachlor + chlorosulfuron -Perspective . daily Federal Register on FederalRegister.gov will remain an unofficial [FR Doc. West Chester, PA 19381 (800) 452-9994. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Hangzhou,Shanghai. (We`ll never share your email address with a third-party.). documents in the last year, 522 Chronic dietary risks are below the Agency's level of concern: 6.6% of the chronic population adjusted dose (cPAD) for children 1 to 2 years old, the population group receiving the greatest exposure. %PDF-1.6
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Chronic risk. Register documents. Adequate enforcement methodology (Method GRM020.01A, which utilizes high performance liquid chromatography with triple-quadrupole mass spectrometry (LC-MS/MS)) is available to enforce the tolerance expression. When low carrier volumes are coupled with finer spray particles, it seems that lower product rates can be used because foliar coverage is maximized. on Please note that, to comply with Canada's . ).However, the seed yield responses of annual ryegrass (Lolium multiflorum Lam.) Chris Hartwiger, director, USGA Course Consulting Service chartwiger@usga.org, Steve Kammerer, Ph.D., regional director skammerer@usga.org, Addison Barden, agronomist abarden@usga.org, Information on the USGAs Course Consulting Service. Slowing flushes of warm-season turf growth with applications of trinexapac-ethyl i.e., Primo MAXX or post-patent products is an important part of reducing mowing inputs and other labor costs. EPA will submit a report containing this rule and other required information to the U.S. Senate, the U.S. House of Representatives, and the Comptroller General of the United States prior to publication of this final rule in the Federal Register. documents in the last year, 24 Additionally, T-NEX is the perfect pre-stress conditioning choice for the coming season. For information regarding EPA's efforts to determine which chemicals have a common mechanism of toxicity and to evaluate the cumulative effects of such chemicals, see EPA's Web site at http://www.epa.gov/pesticides/cumulative. Trinexapac-ethyl can be used in many areas that can be frequented by the general population including residential areas (e.g., home lawns, recreational turf). The Office of Management and Budget (OMB) has exempted these types of actions from review under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). All documents in the docket are listed in the docket index available at http://www.regulations.gov. Then store and dispose of according to local regulations. to the courts under 44 U.S.C. Trinexapac-Ethyl C13H16O5 at Best Price in Mumbai, Maharashtra | National Analytical Corporation - Chemical Division 100 Onwards INR Get Latest Price Minimum Order Quantity : 1 Kilograms/Kilograms Molecular Weight 252.26 Grams (g) Molecular Formula C13H16O5 View more details Accepts all Domestic/Foreign inquiries Send Inquiry Petition 0F7719 requested that 40 CFR part 180 be amended by establishing tolerances for residues of the plant growth regulator, trinexapac-ethyl and its primary metabolite CGA-179500, in or on grass, forage, grown for seed at 1.60 parts per million (ppm); grass, hay, grown for seed at 3.5 ppm; grass, seed screenings, grown for seed at 45.0 ppm; grass, straw, grown for seed at 12 ppm; cattle (fat, meat, meat byproducts) at 0.05 ppm; goat (fat, meat, meat byproducts) at 0.05 ppm; horse (fat, meat, meat byproducts) at 0.05 ppm and sheep (fat, meat, meat byproducts) at 0.05 ppm. Statutory and Executive Order Reviews, PART 180TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD, https://www.federalregister.gov/d/2020-23040, MODS: Government Publishing Office metadata, http://www.ecfr.gov/cgi-bin/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl, http://www.epa.gov/dockets/contacts.html. The Office of Management and Budget (OMB) has exempted these types of actions from review under Executive Order 12866, entitled Regulatory Planning and Review (58 FR 51735, October 4, 1993). We conducteda separate trial evaluating Palisade in drought stress environments that was partially funded by Syngenta. documents in the last year, by the Centers for Medicare & Medicaid Services Suppliers of Trinexapac-ethyl Download SDS (editable Word file) and other types SDS | Offered by XiXisys.com SAFETY DATA SHEETS According to the UN GHS revision 8 Version: 1.0 Creation Date: July 15, 2019 Revision Date: July 15, 2019 SECTION 1: Identification 1.1 GHS Product identifier Product name Box 18300, Greensboro, NC 27419. Until the ACFR grants it official status, the XML Room temperature in continental US; may vary elsewhere. 02/28/2023, 828 Further information regarding EPA drinking water models used in pesticide exposure assessment can be found at http://www.epa.gov/oppefed1/models/water/index.htm. In 2022, the global top five. That document contains a summary of the toxicological profile, a reference to toxicological endpoints, a description of EPA's position on the potential for cumulative risk, as well as the rationale for the Agency's determination regarding the children's safety factor. Trinexapac-ethyl effects on red clover seed crops . Trinexapac-ethyl is a synthetic plant growth regulator that is derived from cyclohexanecarboxylate. In this Issue, Documents This repetition of headings to form internal navigation links documents in the last year, 861 The literature also shows that reduction in lodging is relative to the straw strength of the variety. 346a, any person may file an objection to any aspect of this regulation Start Printed Page 12741and may also request a hearing on those objections. Determination of safety. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. For non-threshold risks, the Agency assumes that any amount of exposure will lead to some degree of risk. Dietary Exposure Evaluation Model (DEEMTM) 7.81 default concentration factors were used to estimate residues of trinexapac-ethyl in processed commodities. In adult animals (rats, rabbits, mice, dogs), no systemic adverse effects are seen below the limit dose following subchronic or chronic oral exposure with the exception of dogs. publication in the future. Relevant information about this document from Regulations.gov provides additional context. About the Federal Register endstream
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Using the exposure assumptions described in this unit, EPA has concluded the combined food, water, and adult post-application dermal exposures result in aggregate MOEs of 761 for liquid products and 601 for granular products. 346a(d)(3), announcing the filing of two pesticide petitions (PP 0F7719 and 0F7720) by Syngenta Crop Protection, Inc., P.O. In addition, EPA periodically reevaluates pesticides to ensure their safety in light of new scientific and regulatory information. Aggregate Risk Assessment and Determination of Safety, D. Revisions to Petitioned-For Tolerances, VI. [Reserved], [FR Doc. Table 1Summary of Toxicological Doses and Endpoints for Trinexapac-ethyl for Use in Human Health Risk Assessment. This regulation establishes tolerances for residues of trinexapac-ethyl in or on sugarcane, cane and sugarcane, molasses. Incidental oral (short and intermediate-term), No appropriate endpoint for the incidental oral scenario for children, Dermal & Inhalation (short- and intermediate-term-adults only), Dermal (or oral) study NOAEL = 60 mg/kg/day (dermal absorption rate = 77.5%. In the Federal Register of March 3, 2020 (85 FR 12454) (FRL-10005-58), EPA issued a document pursuant to FFDCA section 408(d)(3), 21 U.S.C. documents in the last year, 36 Contacts. 2023 United States Golf Association. The docket for this action, identified by docket identification (ID) number EPA-HQ-OPP-2020-0046, is available at http://www.regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP Docket) in the Environmental Protection Agency Docket Center (EPA/DC), West William Jefferson Clinton Bldg., Rm. We conducted the trial at Stillwater (Irr), Perkins (Irr), and Chickasha (Non-Irr). Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. Ensure adequate ventilation. The USGA promotes and conserves the true spirit of the game of golf as embodied in its ancient and honorable traditions. It is not an official legal edition of the Federal The treatments were two nitrogen fertilization doses (60 and 20 kg ha-1), three wheat cultivars (BRS 208, BRS 220, and BRS . EPA published a final rule in the Federal Register on May 20, 2015 (80 FR 28843) (FRL-9926-62) establishing tolerances for residues of trinexapac-ethyl in or on rice and rye commodities based on the Agency's conclusion that there is a reasonable certainty that no harm will result from aggregate exposure to trinexapac-ethyl to the general population, including infants and children. Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. To ensure proper receipt by EPA, you must identify docket ID number EPA-HQ-OPP-2020-0046 in the subject line on the first page of your submission. Certain other material, such as copyrighted material, is not placed on the Internet and will be publicly available only in hard copy form. documents in the last year, 474 In general. EPA has also considered available information concerning the variability of the sensitivities of major identifiable subgroups of consumers, including infants and children. Therefore, tolerances are established for residues of trinexapac-ethyl, including its metabolites and degradates, as set forth in the regulatory text. Trinexepac-ethyl Brand: PrimeraOne Downloads: Label , SDS Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. 601 et seq. Developmental rabbit study. Section 408(b)(2)(C) of FFDCA requires EPA to give special consideration to exposure of infants and children to the pesticide chemical residue in establishing a tolerance and to ensure that there is a reasonable certainty that no harm will result to infants and children from aggregate exposure to the pesticide chemical residue. In applying this provision, EPA either retains the default value of 10X, or uses a different additional safety factor when reliable data available to EPA support the choice of a different factor. The lesions remained confined to the supporting cells in the central nervous system and did not progress to more advanced or more extensive damage of the nervous tissue. Further information regarding EPA standard assumptions and generic inputs for residential exposures may be found at http://www.epa.gov/pesticides/trac/science/trac6a05.pdf. In estimating acute dietary exposure, EPA used food consumption information from the U.S. Department of Agriculture (USDA) 1994-1996 and 1998 Nationwide Continuing Surveys of Food Intake by Individuals (CSFII). ADI. Trinexapac (free acid) 112ZF04MPX Cyclohexanecarboxylic acid, 4- (cyclopropylcarbonyl)-3,5-dioxo- Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo- Trinexapac acid 4- (Cyclopropyl (hydroxy)methylene)-3,5-dioxocyclohexanecarboxylic acid UNII-112ZF04MPX Trinexapac [ISO] SCHEMBL125835 CHEBI:83454 DTXSID90559517 DTXSID501019900 the Federal Register. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. | Home | Index of common names | Pesticideclassification| SiteMap|
Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. Comments were received on the notice of filing. The Public Inspection page Seed weight was generally inversely related to yield; trinexapac-ethyl treatments that produced the highest yield also had the lowest seed weight. - Double-bond stereo. Each document posted on the site includes a link to the Monks, T.G. A quantitative and confirmatory method for the analysis of trinexapac (free acid metabolite of trinexapac-ethyl) in wheat is described. For complete information about, and access to, our official publications Emergency exemptions may be requested by a state or federal agency. Developmental rabbit study. Trinexapac-ethyl is classified as Not likely to be carcinogenic to humans. The combined chronic toxicity/carcinogenicity study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans. ABSTRACT. 2020-23040 Filed 11-3-20; 8:45 am], updated on 4:15 PM on Tuesday, February 28, 2023, updated on 8:45 AM on Tuesday, February 28, 2023, 104 documents Enter your email address to follow this blog and receive notifications of new posts by email. Health considerations documents in the last year, 24 Because EPA's level of concern for trinexapac-ethyl is a MOE of 100 or below, these MOEs are not of concern. from 47 agencies. 4. If appropriate, moisten first to prevent dusting. In making its tolerance decisions, EPA seeks to harmonize U.S. tolerances with international standards whenever possible, consistent with U.S. food safety standards and agricultural practices. daily Federal Register on FederalRegister.gov will remain an unofficial LOC for MOE = 100. While every effort has been made to ensure that corresponding official PDF file on govinfo.gov. These markup elements allow the user to see how the document follows the We rated plots for lodging at harvest using a 1 10 scale with 0 equaling no lodging and 10 equaling complete lodging. For more information on the general principles EPA uses in risk characterization and a complete description of the risk assessment process, see http://www.epa.gov/pesticides/factsheets/riskassess.htm. In making its tolerance decisions, EPA seeks to harmonize U.S. tolerances with international standards whenever possible, consistent with U.S. food safety standards and agricultural practices. Bispyribac-sodium selectively controls annual bluegrass in cool-season turf but efficacy may be influenced by management practices, such as plant growth regulator use. Chemical Name: Trinexapac-ethyl: Section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizes EPA to allow an unregistered use of a pesticide for a limited time if EPA determines that an emergency condition exists. What are the uses of Trinexapac-ethyl ? AXS Fan Account gives you the ability to view, send, or sell your tickets as well as purchase additional tickets and view your account history. Do not let the chemical enter drains. Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. documents in the last year, by the Fish and Wildlife Service informational resource until the Administrative Committee of the Federal Nearest Port. include documents scheduled for later issues, at the request Use water spray, powder, foam, carbon dioxide. Box 18300, Greensboro, NC 27419. rendition of the daily Federal Register on FederalRegister.gov does not Avoid contact with skin and eyes. Compliance with the tolerance levels specified below is to be determined by measuring both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and the associated metabolite, trinexpac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. Trinexapac Ethyl improves rich color and root mass development. %%EOF
This final rule is not a major rule as defined by 5 U.S.C. 346a(d)(3), announcing the filing of a pesticide petition (PP 9F8761) by Syngenta Crop Protection, LLC, P.O. For linear cancer risks, EPA calculates the lifetime probability of acquiring cancer given the estimated aggregate exposure. Information not marked confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. There was no lodging for any site or treatment in 2014. Dietary exposure from drinking water. Wear suitable protective clothing. legal research should verify their results against an official edition of Petition 0F7720 requested that 40 CFR part 180 be amended by establishing tolerances for residues in or on barley, grain at 1.6 ppm; barley, hay at 0.7 ppm; barley, straw at 0.35 ppm; cattle, kidney at 0.05 ppm; hog, kidney at 0.05 ppm; oat, forage at 1.0 ppm; oat, grain at 4.1 ppm; oat, hay at 1.3 ppm; oat, straw at 0.7 ppm; sugarcane, cane at 0.8 ppm; wheat, forage at 1.0 ppm; wheat, grain at 4.1 ppm; wheat, hay at 1.3 ppm and wheat, straw at 0.7 ppm. and services, go to // -->
These setups such as with a boomless nozzle require higher actual product rates. The Docket Facility is open from 8:30 a.m. to 4 p.m., Monday through Friday, excluding legal holidays. Therefore, apply trinexapac-ethyl in 20 to 30 gallons of water per acre. Acute dietary (General population including infants and children), No appropriate endpoint for the general population including infants and children, Chronic RfD = 0.32 mg/kg/day cPAD = 0.32 mg/kg/day. EPA uses the term post-application to describe exposure to individuals that occur as a result of being in an environment that has been previously treated with a pesticide. And regulatory information, 522 this document electronically, please go to:. The OCSPP test guidelines referenced in this document electronically, please go to http: //www.regulations.gov in the,... 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