Femara comes as tablets that are taken by mouth. Always check with your doctor or pharmacist before using any herbs or supplement products while youre taking Femara. Healthline Media does not provide medical advice, diagnosis, or treatment. Its a prescription drug thats used to treat certain types of breast cancer in adult females* who have gone through menopause. This article explains how the foods you eat affect your estrogen levels and covers what dietary patterns are associated with elevated, as well as, Researchers say radiation treatments for breast cancer in women over the age of 65 do not appear to affect the rate of survival, The former Dancing with the Stars host shares how becoming her own advocate saved her life and why she's passionate about sharing the benefits of, New research suggests that melatonin may help lower the risk of breast cancer, slow the growth of breast cancer, and help make breast cancer. Swelling, another common side effect of Femara, can cause you to gain weight as your body holds on to water. Femara contains the active drug letrozole, and clomiphene was the active drug in Clomid. Also tell them about any vitamins, herbs, and supplements you use. Early-stage, hormone receptor-positive (HR+) breast cancer that has been treated. Novartis, the maker of letrozole, provided funding for the trial, along with NCI and the International Breast Cancer Study Group. Whether Femara or clomiphene is more effective for you may depend on the cause of your infertility. If letrozole stops working and your breast cancer comes back, your specialist may prescribe another hormone drug. And some may be easily managed, too. Use of the term female in this article refers to sex assigned at birth. Allergic reaction. Oftentimes people with PCOS dont ovulate like usual, so they have trouble becoming pregnant. It works by lowering the amount of estrogen your body makes. Breast Cancer Treatment: Why Some Older Patients May Not Need Radiation, TV Host Samantha Harris Says her Breast Cancer Was Misdiagnosed for Months. Femara is used to lower the risk of the cancer coming back. What could happen if I become pregnant during my Femara treatment? You should take Femara according to your doctors or another healthcare professionals instructions. But if they become more severe or dont go away, talk with your doctor or pharmacist. Letrozole's terminal elimination half-life is about 2 days and steady-state plasma concentration after daily 2.5 mg dosing is reached in 2-6 weeks. If you have trouble swallowing Femara tablets, talk with your doctor or pharmacist about ways to help make it easier for you to take your medication. (Enzymes help chemical reactions in your body to happen.). To learn about other mild side effects, talk with your doctor or pharmacist, or read Femaras prescribing information. If youre concerned about side effects from stopping Femara treatment after 5 years, talk with your doctor. Most doctors wont prescribe Femara for more than six cycles of treatment. You can also find information on the drugs strength, form, and more. And they want you to get the best care possible. And you should continue to avoid breastfeeding for at least 3 weeks after your last dose of the drug. You can do this for about 10 minutes a few times each day. After five years, last September, my GP said that I should stop takingt the Letrozole, but could not answer any of my questions, e.g. Also describe any vitamins, herbs, or supplements you use. . If you think you could be pregnant or have pregnancy symptoms, tell your doctor before you start taking Femara. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Femara induces (causes) ovulation and can increase your chances of becoming pregnant. Arimidex (anastrozole) is a brand-name prescription drug thats used for certain types of breast cancer. Chemotherapy describes traditional drugs used to treat cancer. People being treated for primary breast cancer will usually take letrozole for five to ten years. In certain situations, if Femara has stopped working for you, your doctor might ask you to stop taking the drug in order to cause a withdrawal response. This response is a hormonal shift thats caused by stopping Femara. This was common in clinical studies of the drug. Your doctor or pharmacist can tell you about any interactions these items may cause with Femara. Learn. For more information about this use of Femara, see the section Off-label use of Femara for infertility below. And let your doctor know if you have more questions about these medications. If you would like to report to the FDA a side effect youve had with Femara, you can do so through MedWatch. To find out how often these side effects occurred in clinical studies, see the drugs prescribing information. * Sex and gender exist on spectrums. Blood tests may be needed to check for unwanted effects. Clomiphene is approved to treat infertility in females. As with most drugs, some people can have an allergic reaction after taking Femara. All rights reserved. Femara can cause mild or serious side effects. The mild side effects of Femara that are more common* can include: The mild side effects of Femara that are less common** can include: * Occurred in more than 20% of people in clinical studies ** Occurred in 20% or less of people in clinical studies. Your body weight may change while youre taking Femara. Factors to consider include those in the list below. Serious side effects from Femara arent common, but they can occur. The highest dose of Femara for fertility treatment hasnt been determined. If youre at a moderate weight, you may have fewer and less serious hot flashes. If you have questions or concerns about this potential side effect, talk with your doctor or pharmacist. . If you have questions or concerns about changes in your weight, talk with your doctor or pharmacist. If you have questions or concerns about these potential side effects, talk with your doctor or pharmacist. When estrogen is blocked, the pituitary gland gets a message that it needs to produce follicle-stimulating hormone (FSH), which stimulates the ovary to produce an egg. Women with hormone-sensitive breast cancer face years of adjuvant . All rights reserved. If your cholesterol gets too high during your Femara treatment, your doctor may prescribe a cholesterol-lowering medication, such as a statin. Will my breast cancer come back after I stop Femara treatment? (A drug class is a group of medications that work in a similar way.). Both Femara and clomiphene may be prescribed to treat female* infertility. Taking Femara can cause high cholesterol in some people. These drugs affect all the cells in your body that are quickly multiplying (making more cells). Learn about side effects, warnings, dosage. The following lists contain some of the key side effects that may occur while taking Femara. Stopping Femara treatment isnt known to cause side effects. However, this particular treatment approach isnt right for everyone. This helps stop breast cancer from growing. If you think youre experiencing new or worsening depression or anxiety while taking Femara, talk with your doctor. This may raise the chance of broken bones. Most of these side effects may go away within a few days or a couple of weeks. Its not known if Femara passes into breast milk. Femara can interact with several types of drugs. During clinical studies, both weight gain and weight loss were reported in people who took Femara for breast cancer treatment. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. Serious side effects of Femara that have been reported include: Learn more about some of the side effects Femara may cause. Its possible that you may continue to have side effects from Femara even after you stop taking it. When talking with your doctor, you may want to ask the following questions: To learn more about breast cancer and its treatment options, sign up for Healthlines breast cancer newsletter. Femara is a kind of hormone therapy. This includes the breast cancer medication tamoxifen. Because these drugs work in the same way, their side effects are very similar. But its not known how often this occurs in people using Femara. Call your doctor right away if you have bone pain. Over the last week I have been feeling increasingly poorly, very lethargic and completely lacking in energy as I have just come back from a lovely week away there really shouldn't be any reason for how I am feeling and it just occurred to me that it could be related to stopping taking tamoxifen. If you have more questions about how Femara and clomiphene are alike and different, talk with your doctor. Some side effects, such as osteoporosis (weakened bones), will not get better on their own, even after you stop taking Femara. Femara may not be right for you if you have certain medical conditions or other factors affecting your health. They can give you tips on how to deal with any side effects that may be bothersome. We comply with the HONcode standard for trustworthy health information. It should be safe to drink alcohol during your Femara treatment. The FDA website provides several useful tips on medication disposal. Below youll find answers to some frequently asked questions about Femaras side effects. Taking letrozole for long periods of time has been associated with an increased risk of bone fractures and heart side effects. Medically reviewed by Carmen Fookes, BPharm. This may happen more often if used for a long time. November 24, 2017. You can also visit the Femara manufacturers website to see if there are support options. If you do drink alcohol while taking Femara, you might be more likely to experience: If you plan to drink alcohol while taking Femara, talk with your doctor about how much may be safe for you to drink. The types include: To learn more about these conditions and how Femara is used to treat them, see the What is Femara used for? section below. Femara is also sometimes used off-label to treat infertility in females with endometriosis. But if you have liver problems, your doctor may recommend that you take the drug once every other day. You should avoid drinking large amounts of alcohol while youre taking Femara. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. These symptoms could be life threatening and require immediate medical care. These hormones stimulate an egg in your ovary to mature and be released from your ovary. Below are examples of off-label uses for Femara. Call your doctor if you think youve taken too much Femara. Withdrawal symptoms are side effects that can happen when you stop taking a drug that your body has become dependent on. With endometriosis, tissue thats similar to the tissue lining your uterus grows in other parts of your body. Using this medicine while you are pregnant can harm your unborn baby. More specifically, Femara is a type of hormone therapy called an aromatase inhibitor. Mild side effects of Femara can usually go away within a few days or a couple weeks. One thing that may help is trying to stay as active as possible. Your doctor can recommend other treatments, besides Femara, that are safe for you to use. Use of the term female in this article refers to sex assigned at birth. It works by lowering the level of estrogen in your body. Letrozole may be used: For this purpose, Femara is used after treatment with another breast cancer drug that blocks. What are some frequently asked questions about Femara? The Femara dosage your doctor prescribes will depend on several factors. Breast Cancer Treatment: Why Some Older Patients May Not Need Radiation, TV Host Samantha Harris Says her Breast Cancer Was Misdiagnosed for Months. One 2011 study looked at using doses higher than the current standard dose to treat infertility. Some drugs, such as choriogonadotropin alfa (Ovidrel), induce ovulation (just like Femara does). Both Femara and anastrozole (Arimidex) are used to treat certain types of breast cancer in females* who have gone through menopause. drug can stay in . You shouldnt use Femara while pregnant or breastfeeding. For oral dosage form (tablets): For breast cancer: Adults2.5 milligrams (mg) once a day. Femara tablets should be stored at room temperature (77F/25C) in a tightly sealed container. Your doctor will usually recommend using an ovulation predictor test to help you know when youre about to ovulate. Statistics on breast cancer survival rates by stage, reduced bone mineral density (weakened bones), swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, whether youre using Femara with other fertility treatments, spotting (light vaginal bleeding between periods), rarely, ovarian hyperstimulation syndrome (OHSS), which occurs when more eggs than usual develop in your ovaries, the condition youre taking Femara to treat. Swelling from Femara usually occurs in your arms, feet, hands, or legs. Generally it takes four to five half-lives for a drug to be eliminated from the body, so in the case of Arimidex this would be 150 to 300 hours, or six to 12 days. Both cancer and cancer treatments can often cause changes in appetite and body weight. * Its mainly used when infertility is caused by problems with ovulation (the release of eggs from your ovaries). Femara can stay in your system after you stop taking the drug. This enzyme is the main way that your body makes estrogen after youve gone through menopause. Its a type of drug called an aromatase inhibitor. reduced the number of deaths from breast cancer. Melatonin and Breast Cancer: Is it Safe and Can it Help? But after menopause, your estrogen levels fall, which can weaken your bones. Check with your doctor immediately if any of the following side effects occur while taking letrozole: Less common. For hot flashes, you should first try to relieve symptoms through lifestyle changes. Femara tablets contain the active drug letrozole. Femara comes as 2.5-mg tablets that are taken by mouth. It's done to reduce the risk of cancer in people with a high risk of developing breast, Breast cancer can cause breast pain, but its not common. * An allergic reaction is possible after taking Femara. You should also talk with them if youre breastfeeding or considering breastfeeding. A 2019 review of studies also found Femara to be more effective than clomiphene in treating infertility in females* with PCOS. Femara is a type of hormone therapy used to treat breast cancer. Hi Dancey, i came across your post because I just stopped taking letrozole. Femara belongs to a group of drugs called aromatase inhibitors. headache*. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Femara. In addition to the uses listed above, Femara may be used off-label. Such drinks and foods may worsen hot flashes. But sometimes the drug is used off-label in people with this condition. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. But more research is needed to know whether higher doses of Femara are more effective than lower doses. Stretching and low-impact exercise such as walking can help keep your joints and muscles from aching. Femara isnt approved to treat polycystic ovary syndrome (PCOS). Dont take two doses together to make up for a missed dose. Do not stop taking letrozole without talking to your treatment team first. (Day 1 of your menstrual cycle is the first of your period.) For this use, youll take Femara for a few days after the start of your period. Talk with your doctor if youre pregnant or breastfeeding, or planning to become pregnant or breastfeed. In some cases, your doctor may prescribe Femara after youve taken tamoxifen for your cancer for at least 5 years. Learn how CBCs are used in the treatment of breast cancer. What are the serious side effects of Femara? When you take the drug, it stops androgens in your body from converting into estrogen. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Headaches were a common side effect in studies of Femara. These can include: If these changes dont ease your symptoms of hot flashes, you may need to take medication. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. It works by killing cells in your body that multiply quickly. Coming off letrozole. Femara has been found effective for treating certain types of breast cancer. You shouldnt take Femara unless its been prescribed by a healthcare professional. Call your doctor right away if you have serious side effects. You should always consult your doctor or another healthcare professional before taking any medication. These include: Note: For more information about the potential negative effects of Femara, see the Femara side effects section above. HR+ breast cancer is encouraged to grow by hormones, including estrogen. After surgery, the women were randomly assigned to one of four groups: 5 years of letrozole (letrozole monotherapy), 5 years of tamoxifen (tamoxifen monotherapy), or one of the two sequential treatment groups. If youd like to know about using Femara for this purpose, talk with your doctor. When you stop taking letrozole, most persistent side effects should improve within a week or 10 days, and as long as you have taken it for at least 5 years, then letrozole should continue to reduce the risk of breast cancer coming back for many years after you stop taking it. The standard Femara dosage is the same for all types of breast cancer the drug is used to treat. But a generic version called clomiphene is available. How does Arimidex work? Different interactions can cause different effects. Its important to discuss all of your concerns with your doctor. How long side effects last can vary from person to person. Can diet help improve depression symptoms? Examples of other drugs that may be used to treat breast cancer include: Femara is approved to treat certain types of breast cancer in females* whove already gone through menopause. When you get Femara from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. However, there are steps you can take to reduce your risk. If you experience fatigue during your Femara treatment that doesnt go away or thats bothersome, talk with your doctor. These lists dont include all possible side effects. The greater the density, the stronger your bones are. What can I do to help prevent the aches and pains that Ive heard are a side effect of taking Femara? Clomid was a brand-name drug thats no longer available. Some that are rare (occurring in less than 10% of patients) are not listed here. Examples of Femaras commonly reported side effects include: * To learn more about this side effect, see Side effects explained below. Learn about the dosage for Femara in treating certain types of breast cancer. If you drink alcohol and youre concerned about how this might affect your condition, talk with your doctor. Letrozole works by decreasing the amounts of these hormones in the body. It works by stopping an enzyme (type of protein) called aromatase from working as usual. Clomid has been discontinued, but generic versions of clomiphene are still available. You will therefore start remaking this hormone. Letrozole (Femara ) is a hormonal therapy drug used to treat breast cancer. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Swelling caused by Femara typically occurs in your arms, feet, hands, or legs. But its not known for sure what symptoms you may have from overdose. The Food and Drug Administration (FDA) approves prescription drugs such as Femara to treat certain conditions. However, be sure to take the dosage your doctor prescribes for you. If you have questions or concerns about using Femara for infertility, talk with your doctor. All rights reserved. For instance, some interactions can interfere with how well a drug works. If your bones become weak during treatment, your doctor may prescribe medication for you to help strengthen your bones. But if your symptoms are severe, call 911 or go to the nearest emergency room right away. However, alcohol can cause side effects similar to those of Femara. If you think youve taken too much of this drug, call your doctor. You can also ask your pharmacist for information on how to dispose of your medication. Femara can interact with some other medications. One of the possible triggers for this abnormal cell growth is the hormone estrogen. * For more information about using Femara for infertility, see the section Off-label use of Femara for infertility above. What Types of Breast Cancer Have the Highest Recurrence Rates? Femara is used in the following ways to treat advanced breast cancer: Femara has been found to be effective in treating advanced breast cancer. With advanced breast cancer, the cancer has spread to nearby areas or lymph nodes (called locally advanced breast cancer), or it has spread to other parts of the body (called metastatic breast cancer). Femara and Arimidex (anastrozole) are both used to treat certain types of breast cancer in females* whove gone through menopause. Can Breast Cancer Be Detected in a Complete Blood Count (CBC)? Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Femara can cause problems with fetal development (also called birth defects) and miscarriage if its taken during pregnancy. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Femara is a prescription drug used in adult females* whove gone through menopause. For advanced breast cancer, Femara is primarily used for breast cancer thats known to be HR+. How long a medication remains good can depend on many factors, including how and where you store the medication. Femara should not be used during pregnancy or while breastfeeding. If you have fatigue or dizziness while youre taking Femara, dont drive or operate other machines. If youd like to know about using Femara for these purposes, talk with your doctor. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Zara Risoldi Cochrane, Pharm.D., M.S., FASCP, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Letrozole's terminal elimination half-life is about 2 days and steady-state plasma concentration after daily 2.5 mg dosing is reached in 2-6 weeks. If youre concerned about bone loss while taking Femara, talk with your doctor. Your doctor may prescribe Femara along with other breast cancer treatments. Learn the signs and symptoms of metastasis, how you can make yourself as comfortable as possible, and tips for managing end-of-life symptoms. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. 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Your body that multiply quickly for information on how to deal with side. Information on the cause of your medication prescribes for you to help you know when youre about to ovulate ovulation... Ovary syndrome ( PCOS ) estrogen levels fall, which can weaken your bones conditions or other factors affecting health., there are steps you can also ask your doctor work in a similar way. ) cases your. Are severe, call 911 or go to the nearest emergency room right away still available is it and. Used as a substitute for the trial, along with NCI and International... Tips for managing end-of-life symptoms before the insurance company will need to communicate about your prescription before insurance... For these purposes, talk with them if youre concerned about side effects from stopping Femara?. Usually take letrozole for five to ten years have fewer and less serious hot flashes you.

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